'Nihilism' is an often stigmatized word in our culture.
But there is the argument that nihilism, functionally, can act as a dialectical tool to level incoherent precepts about the nature of reality down to constituent parts. Of course, people can take this too far to where even the constituent parts are done away with altogether, which leads one ultimately to the position that one can act as though no negative consequences to one's actions matter.
One could think of detachment, in the far eastern sense, as being a different configuration of the commandment, 'Thou shalt have no other gods before Me.' Only the 'Me,' in this case, could be considered the ground of being, which is the metaphysical principle behind the more hypostasisized, anthropomorphized concept we often call 'God' here in the west.
Cities have always been gene-shredders, only made possible by the abundant fecundity of the countryside.